口腔黏膜角化細(xì)胞是口腔疾病主要屏障，保護(hù)局部細(xì)胞免受微生物和化學(xué)物質(zhì)造成的傷害。它們通過(guò)不斷產(chǎn)生或受刺激后產(chǎn)生的細(xì)胞因子，刺激參與促發(fā)炎癥反應(yīng)，這意味著它們可能通過(guò)炎癥過(guò)程潛在地參與口腔感染的調(diào)控，該過(guò)程需要不同的白細(xì)胞介素參與，如IL-1?和IL-18?？谇火つそ腔?xì)胞表達(dá)多種不同的細(xì)胞標(biāo)志物，該表達(dá)受到目標(biāo)基因轉(zhuǎn)錄過(guò)程中鈣素誘導(dǎo)變化的影響。口腔黏膜角化細(xì)胞與特征明顯的皮膚角質(zhì)細(xì)胞在結(jié)構(gòu)和功能上有很大的相似性，并且為研究角質(zhì)細(xì)胞的生物學(xué)特性、無(wú)限增殖過(guò)程、惡性轉(zhuǎn)化提供了良好的模型。
人口腔黏膜角化細(xì)胞提取于人口腔黏膜，一代凍存。每管含有細(xì)胞數(shù)>5×105 cells/ml，此細(xì)胞通過(guò)Cytokeratine-8, -18 and -19免疫熒光染色驗(yàn)證，經(jīng)測(cè)試不含有HIV-1、HBV、HCV、支原體、細(xì)菌、酵母和真菌。細(xì)胞可以達(dá)到15倍增。

推薦培養(yǎng)基：口腔角質(zhì)細(xì)胞培養(yǎng)基 (OKM, Cat. #2611)

貨號(hào)	2610
產(chǎn)地	美國(guó)
縮寫(xiě)	HOK
規(guī)格	5 x 10^5 /1ml
用途	科研
儲(chǔ)存	液氮
運(yùn)輸	干冰
關(guān)鍵字	人口腔角質(zhì)細(xì)胞 HOK 人口腔角質(zhì)細(xì)胞 HOK 人口腔角質(zhì)細(xì)胞 HOK 人口腔角質(zhì)細(xì)胞 HOK 人口腔角質(zhì)細(xì)胞 HOK 人口腔角質(zhì)細(xì)胞 HOK
公司簡(jiǎn)介	合肥星肽生物科技有限公司作為專(zhuān)業(yè)的ScienCell中國(guó)代理商，專(zhuān)業(yè)經(jīng)營(yíng)實(shí)驗(yàn)室科研用原代細(xì)胞、原代細(xì)胞專(zhuān)用培養(yǎng)基、原代細(xì)胞無(wú)血清培養(yǎng)基、干細(xì)胞、干細(xì)胞培養(yǎng)基、干細(xì)胞無(wú)血清培養(yǎng)基的研究和開(kāi)發(fā)。合肥星肽生物科技有限公司始終致力于為客戶(hù)提供可靠的研究材料以及方便快捷的服務(wù)，對(duì)購(gòu)買(mǎi)項(xiàng)目的前期資料提供,中期合同保證,后期貨物跟蹤到終售后的確保項(xiàng)目準(zhǔn)確到位，都有相關(guān)專(zhuān)業(yè)人士進(jìn)行維護(hù),確保您在合肥合肥星肽生物科技有限公司公司獲得上等服務(wù)！
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1.) Yen YC, Shiah SG, Chu HC, Hsu YM, Hsiao JR, Chang JY, Hugn WC, Liao CT, Cheng AJ, Lu YC, Chen YW. (2014) 'Reciprocal regulation of MicroRNA-99a and insulin-like growth factor I receptor signaling in oral squamous cell carcinoma cells.'?Mol cancer.

2.) Yen YC, Shiah SG, Chu HC, Hsu YM, Hsiao JR, Chang JY, Hugn WC, Liao CT, Cheng AJ, Lu YC, Chen YW. (2014) "Reciprocal regulation of MicroRNA-99a and insulin-like growth factor I receptor signaling in oral squamous cell carcinoma cells."?Mol cancer. 13: 6.

3.) Ji W, Lee C, Chen JY, Cheng Y, Yang S, Chen J, Chen H. (2013) "Areca Nut Extract Induces Pyknotic Necrosis in Serum-Starved Oral Cells via Increasing Reactive Oxygen Species and Inhibiting GSK3: An Implication for Cytopathic Effects in Betel Quid Chewers."?PLoS One. 8: e63295.

4.) Wallet MA, Calderon NL, Alonso TR, Choe CS, Catalfamo DL, Lalane CJ, Naiva KG, Panagakos F, Wallet SM. (2013) ?Triclosan alters antimicrobial and inflammatory responses of epithelial cells.??Oral dis.?19: 296-302.

5.) Talwar S, Balasubramanian S, Sundaramurthy S, House R, Wilusz CJ, Kuppuswamy D, D'Silva N, Gillespie MB, Hill EG, Palanisamy V. (2013) "Overexpression of RNA-binding protein CELF1 prevents apoptosis and destabilizes pro-apoptotic mRNAs in oral cancer cells."?RNA Biol. 10: 277-86.

6.) Lee SS, Tsai CH, Yu CC, Chang YC. (2013) "Elevated Snail Expression Mediates Tumor Progression in Areca Quid Chewing-Associated Oral Squamous Cell Carcinoma via Reactive Oxygen Species."?PLoS One. 8: e67985.

7.) Kim JS, Yu SK, Lee MH, Park MG, Park E, Kim SG, Lee SY, Kim CS, Kim HJ, Chun HS, Chun SW, Kim DK. (2013) 'MicroRNA-205 directly regulates the tumor suppressor, interleukin-24, in human KB oral cancer cells.'

8.) Kim JS, Yu SK, Lee MH, Park MG, Park E, Kim SG, Lee SY, Kim CS, Kim HJ, Chun HS, Chun SW, Kim DK. (2013) "MicroRNA-205 directly regulates the tumor suppressor, interleukin-24, in human KB oral cancer cells."?Mol cells. 35: 17-24.

9.) Russo N, Wang X, Liu M, Banerjee R, Goto M, Scanlon C, Metwally t, Inglehart RC, Tsodikov A, Duffy S, Tubergen EV, Bradford C, Carey T, Wolf G, Chinnaiyan AM, D

10.) Kumar B, Yadav A, Lang JC, Cipolla MJ, Schmitt AC, Arradaza N, Teknos TN, Kumar P. (2012) 'YM155 reverses cisplatin resistance in head and neck cancer by decreasing cytoplasmic survivin levels.'

11.) Kumar B, Yadav A, Lang JC, Cipolla MJ, Schmitt AC, Arradaza N, Teknos TN, Kumar P. (2012) "YM155 reverses cisplatin resistance in head and neck cancer by decreasing cytoplasmic survivin levels."?Mol cancer ther.?11: 1988-98.

12.) Van Tubergen E, Vander Broek R, Lee J, Wolf G, Carey T, Bradford C, Prince M, Kirkwood KL, D'Silva NJ. (2011) "Tristetraprolin regulates interleukin-6, which is correlated with tumor progression in patients with head and neck squamous cell carcinoma."?Cancer. 117: 2677-89.

13.) Jiang L, Liu X, Kolokythas A, Yu J, Wang A, Heidbreder CE, Shi F, Zhou X. (2010) "Downregulation of the Rho GTPase signaling pathway is involved in the microRNA-138-mediated inhibition of cell migration and invasion in tongue squamous cell carcinoma."?Int J Cancer. 127: 505-12.

14.) Mitchell C, Joyce AR, Piper JT, McKallip RJ, Fariss MW. (2010) "Role of oxidative stress and MAPK signaling in reference moist smokeless tobacco-induced HOK-16B cell death."?Toxicol Lett. 195: 23-30.

15.) Phan TC, Ooi J, Goonewardene MS. (2010) "A novel molecule, SLURP-1, enhances the survival of periodontal ligament fibroblasts."?J Periodontal Res. 45: 331-6.?

16.) Rao SK, Pavicevic Z, Du Z, Kim JG, Fan M, Jiao Y, Rosebush M, Samant S, Gu W, Pfeffer LM, Nosrat CA. (2010) "Pro-inflammatory genes as biomarkers and therapeutic targets in oral squamous cell carcinoma."?J Biol Chem. 285: 32512-21.

17.) Dowejko A, Bauer RJ, M?ller-Richter UD, Reichert TE. (2009) "The human homolog of the Drosophila headCAS:e protein slows down cell division of head and neck cancer cells."?Carcinogenesis. 30: 1678-85.

18.) Ghosh A, Park JY, Fenno C, Kapila YL. (2008) "Porphyromonas gingivalis, gamma interferon, and a proapoptotic fibronectin matrix form a synergistic trio that induces c-Jun N-terminal kinase 1-mediated nitric oxide generation and cell death."?Infect Immun. 76: 5514-23.

19.) M?ller-Richter UD, Dowejko A, Zhou W, Reichert TE, Driemel O. (2008) "Different expression of MAGE-A-antigens in foetal and ***** keratinocyte cell lines."?Oral Oncol. 44: 628-33.?

20.) Liang SC, Tan XY, Luxenberg DP, Karim R, Dunussi-Joannopoulos K, Collins M, Fouser LA. (2006) "Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides."?J Exp Med. 203: 2271-9.

Question:

I use poly-L-lysine to coat my plate to culture HOK(Human Oral Keratinocytes) cells. I also found out that we have poly-D-lysine. Can I use poly-D-lysine to coat my plate and culture HOK or other primary cells?